| Posaconazole * |
| | . |
| REQUESTING AND COLLECTING |
| | Ordering: | | Collect sample just before the next dose (trough collection). |
| | Collection: | | Do not use gel collection tube. |
| Container(s): | | EDTA (5 mL purple-top) - Required |
| | . |
| | GENERAL INFORMATION |
| | Availability: | | Test performed Twice weekly (usually Tuesday and Thursday) |
| | Reference Intervals: | | Antifungal efficacy and pharmacodynamic studies of posaconazole in |
| | experimental animal models suggest that the time the plasma |
| | concentration remains above the MIC is the most predictive for |
| | efficacy. Trough concentration should be >700 ng/mL for best efficacy |
| | (limited data) and >250 ng/mL for prophylaxis, each at steady state (ie |
| | 7 days after starting therapy). |
| | Laboratory: | | Clinical Pharmacology (8382-9184) |
| | Clinical Hyperlink: | | Posaconazole - SydPath website |
| . |
| INSTRUCTIONS FOR REFERRING LABORATORIES |
| Handling and |
| | Store and transport frozen unless it may take over 12 hours to deliver |
| | to SydPath, if so freeze sample. |
| _______________________________________________________________________ |
| INSTRUCTIONS FOR HANDLING AT SYDPATH |
| SydPath Handling: | | SPRO: Centrifuge at 4°C, aliquot (x1). Place in SPRO freezer. |
| Mnemonic: |
| | GEcode: | | POS |
| | SydPath | | Clinical Pharmacology |
| . |
| Date Published: Monday, 5 July 2010 |