| TEST |
INDICATION |
INTERPRETATION |
| CI
ESTERASE INHIBITOR |
|
- Low levels diagnostic of
hereditary form of angioedema which is also associated with low C4
|
| CH100
or TOTAL HAEMOLYTIC COMPLEMENT |
- Recurrent bacterial infection
- Connective tissue diseases
|
- Congenital deficency will have no
activity
- Low level suggests complement activation
(eg in SLE)
|
| SERUM
COMPLEMENT C3 C4 |
- Detection of complement activation in
SLE, glomerulonephritis and other immune complex diseases
|
- Reduced C3, C4 in immune complex disease
with classical complement pathway activation eg SLE
- Normal C4 and reduced C3 in diseases
with alternative complement pathway activation eg septicaemia, endotoxaemia.
- Reduced C4 and normal C3 in hereditary
angioedema.
- Raised C3, C4 in inflammatory disease eg
RA.
|
| C-REACTIVE
PROTEIN ALPHA-1 ANTITRYPSIN FIBRINOGEN |
- Inflammatory disorders.
- Neoplastic conditions.
- Unexplained high ESR.
- Monitoring disease activity eg
Rheumatoid Arthritis.
- Cardiovascular risk assessment.
|
- Can indicate inflammatory response in
patients with normal ESR
- May distinguish acute from chronic
inflammatory conditions
- CRP at high end of normal range
associated with increased CVS risk.
|
| HAPTOGLOBIN |
- Inflammatory disorders
- Haemolytic anaemia
|
- Elevated in inflammatory diseases
- Decreased in haemolytic anaemia
|
